Computational Biology Research Center[CBRC]

Released on 8th Feb. 2013.

　International conference GLOBAL HEALTH 2012 was held in Venice, Italy from 21 to 26 October, 2012. In this conference, 28% - 42% of articles were adopted as oral presentation. Among the oral presentation, some papers have been selected as "Best Papers" based on the reviews of the original submission, the camera-ready version, and the presentation during the conference. The article written by Sachiyo Aburatani, one of the research scientists of CBRC, was awarded as "Best papers".

Web Page：　http://www.iaria.org/conferences2012/AwardsGLOBALHEALTH12.html

About Article

• Title：Application of Structural Equation Modeling for Inferring Toxicity-Dependent Regulation in Human Embryonic Stem Cells
• Author:Sachiyo Aburatani, Wataru Fujibuchi

　Abstract─ Chemical toxicity threat our daily health, especially for embryos. Reveling toxicity-dependant regulation in human embryo is one of the effective approaches to prevent some chemical effects. In previous study, we developed a network inference approach, based on Structural Equation Modeling (SEM). In this study, we improved the SEM approach and applied this enhanced approach to expression profiles in human embryonic stem cells exposed to various chemicals. The inferred gene regulatory models among neurodevelopment related genes clarify the differences between chemicals, and the network shapes reflected the features of chemical toxicities. The effects of Acrylamide toxicity finally aggregated to a neuronal cell-related gene, even though Diethylnitrosamine disturbed normal cell differentiation-related genes. Furthermore, gene regulatory network with Thalidomide was complicated, but embryonic development-related genes were estimated as the finally effected genes by Thalidomide toxicity.