Comparative Genomics Research Group

Research Topics

Pair-wise and multiple alignment of protein and genomic sequences
Fast genome mapping and spliced alignment of transcripts for discovery and structural prediction of eukaryotic genes
Analysis of function, structure, sequence, and evolution (FESS) relationships of cytochrome P450 gene superfamily

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Team Member

Osamu Gotoh
Invited Senior Research Scientist E-mail
Osamu Gotoh
Key Words

sequence analysis, sequence alignment, gene finding, comparative genomics, gene evolution, cytochrome P450

Mariko Morita
Research Staff
Key Words

gene finding, drug metabolism, cytochrome P450

Papers List

  • Gotoh, O. (1992) Substrate recognition sites in cytochrome P450 family 2 (CYP2) proteins inferred from comparative analyses of amino acid and coding nucleotide sequences. J. Biol. Chem. 267, pp.83-90.
  • Gotoh, O. (1996) Significant improvement in accuracy of multiple protein sequence alignments by iterative refinement as assessed by reference to structural alignments. J. Mol. Biol. 264, pp.823-838.
  • Nakato, R. and Gotoh, O. (2010) Cgaln: fast and space-efficient whole-genome alignment. BMC Bioinformatics, 11, 224.
  • Ichinose, N., Yada, T., Gotoh, O. (2012) A large-scale motif discovery using a DNA Gray code and equiprobable oligomers, Bioinformatics, 28, pp.25-31.
  • Iwata, H. and Gotoh, O. (2012) Benchmarking spliced alignment programs including an extended version of spaln (spaln2) that incorporates additional species-specific features, Nucleic Acid Res., in press.
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