Various aspects of protein-protein interaction (PPI) have been investigated by combining different types of molecular information. New methods to predict PPI and the interface for PPI have been developed in the studies.
Enzyme structures and functions, including enzyme reaction mechanisms, have been analyzed and classified, in order to develop the enzyme reaction database, EzCatDB, as well as the enzyme-related softwares. Along with enzymes, enzyme-related biomolecules have also been analyzed.
protein, amino acid sequence, nucleotide sequence, tertiary structure, protein-protein interaction, homology, molecular evolution
Enzyme, Catalytic mechanism, Catalysis, Protein, 3D-structure, Tertiary structure, Catalytic function, Classification database, Ligand, Compound, Intermediate analyses, EzCatDB
molecular dynamics, replica exchange method, protein folding, amyloid and aggregation¡¡
protein modeling, in silico screening, drug design, molecular simulation, G protein-coupled receptors
molecular dynamics protein stability, folding, tertiary structure prediction