Sequence Analysis Team

Research Topics

Sequence alignment

1.Genome Sequence Similarity Search (LAST)
2.Effective Repeat Masking (TanTan)

Next-gen Sequence Data Correction (RECOUNT)

Protein Subcellular Localization (WoLF PSORT)

1.Nuclear Export Signal Prediction (NESsential)
2.Mitochondrial Protein Targeting and Cleavage Prediction
3.Mitosomal Proteome Sequence Analysis

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Team Member

Paul Horton
Leader E-mail
Paul Houton
Key Words

Genome Sequence Analysis, Protein localization prediction, Motif Discovery, Gene Expression Analysis, NGS data processing methods

Martin Frith
Key Words

genome evolution, motifs, genome function, alignment, repeats

Kenichiro Imai
Key Words

Subcellualar localization of protein, Sorting signal Analysis, Mitochondrial protein

Thomas Poulsen
Research Staff
Key Words

Sequence alignment, Series quantification, Localization prediction.

Papers List

  • "Mammalian NUMT insertion is non-random",
    Junko Tsuji, Martin C. Frith, Kentaro Tomii & Paul Horton
    Nucleic Acids Research, in press.
  • "A mostly traditional approach improves alignment of bisulfite-converted DNA",
    Martin C. Frith, Ryota Mori & Kiyoshi Asai
    Nucleic Acids Research, 2012.
  • "RecountDB: a database of mapped and count corrected transcribed sequences",
    Edward Wijaya, Martin C. Frith, Kiyoshi Asai & Paul Horton
    Nucleic Acids Research, (2012 NAR Database Issue)
  • "Prediction of leucine-rich nuclear export signal containing proteins with NESsential",
    Szu-Chin Fu, Kenichiro Imai & Paul Horton
    published online Nucleic Acids Research, June 24, 2011.
  • "Eukaryotic-wide sequence analysis of mitochondrial -barrel outer membrane proteins",
    Kenichiro Imai, Naoya Fujita, M. Micheal Gromiha & Paul Horton
    BMC Genomics, 12:79, 2011.
  • "Adaptive seeds tame genomic sequence comparison",
    S.M. Kie?basa, Raymond Wan, Kengo Sato, Paul Horton & Martin C. Frith
    Genome Research, 21:487-93, 2011.
  • "A new repeat-masking method enables specific detection of homologous sequences",
    Martin C. Frith
    Nucleic Acids Research, 39:e23, 2010.
  • "Incorporating sequence quality data into alignment improves DNA read mapping",
    Martin C. Frith, Raymond Wan & Paul Horton
    Nucleic Acids Research, 38(7):e100, 2010.
  • "Parameters for accurate genome alignment",
    Martin C. Frith, Michiaki Hamada & Paul Horton
    BMC Bioinformatics 11:80, Feb 9 2010.
  • "Mitochondrial -Barrel Proteins, an Exclusive Club?"(Correspondence),
    Kenichiro Imai, M. Michael Gromiha & Paul Horton
    Cell, 135(7):1158-9, 2008.
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